MEDLINE Journals

    A randomized double-blind clinical trial of xipamid and hydrochlorothiazide in essential hypertension.

    Authors
    Kumar S, Pandhi P, Wahi PL, et al. 
    Source
    Int J Clin Pharmacol Ther Toxicol 1984 Oct; 22(10) :549-51.
    Abstract

    Seventeen patients with mild to moderate essential hypertension and controlled with antihypertensive drugs were treated with xipamid (40 mg) or hydrochlorothiazide (50 mg) in a double-blind cross-over randomized trial design. After a run-in-period of 2 weeks with placebo, all of them received either of the two drugs. Placebo treatment for 2 weeks decreased both supine as well as standing blood pressure, but it was not statistically significant. Xipamid produced a somewhat greater decrease in blood pressure than hydrochlorothiazide, but the difference was not statistically significant. Similar results were obtained in 12 newly diagnosed cases of mild to moderate essential hypertension treated with xipamid (80 mg) or hydrochlorothiazide (100 mg) daily as single drug treatment in a randomized, double-blind parallel design trial. The side effects produced by both drugs were only mild in nature. No significant changes were produced in serum electrolytes, uric acid and fasting blood glucose in this short term study with either of the drugs.

    Mesh
    Blood Pressure
    Clinical Trials as Topic
    Diuretics
    Double-Blind Method
    Humans
    Hydrochlorothiazide
    Hypertension
    Random Allocation
    Xipamide
    Language

    eng

    Pub Type(s)
    Clinical Trial Comparative Study Journal Article
    PubMed ID

    6392119

    Content Manager
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