- Beta-blockers may be initiated to reduce the rate of aneurysm expansion (2)[C].
- Beta-blockers should be used perioperatively in absence of contraindications (2)[A]; bronchodilators should be used for 2 weeks prior to repair for patients with COPD (1)[C].
- Statins may be beneficial perioperatively, but have not been shown to inhibit future expansion despite initial reports. Research on this topic is ongoing (5).
- Aspirin may inhibit expansion by inhibiting thrombus growth (5)[C].
- Doxycycline may also inhibit expansion, but further studies are needed. Early animal studies indicate a possible role for angiotensin-converting enzyme (ACE)-I/angiotensin receptor blockers (ARBs), mast cell stabilizers, prostaglandin inhibitors, and novel gene therapy (2).
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