Explore 5-Minute Clinical Consult - view these FREE monographs:
-- The first section of this topic is shown below --
- A rare American STD characterized by painful genital ulcerations and inflammatory inguinal adenopathy.
- Although uncommon in the US, it is found worldwide.
- Chancroid is endemic in developing countries, especially sub-Saharan Africa, and is a cofactor for HIV transmission.
- <50 cases reported to CDC in 2004–2010
- Actual numbers are considered higher due to lack of testing and thus underreporting.
- Endemic in developing countries; annual estimated global prevalence of 4–6 million, but actual prevalence is unknown due to lack of testing
- Thought to be extremely common in:
- Sub-Saharan Africa
- Southeast Asia
- Latin America
- Multiple sexual partners
- Uncircumcised men
- Prostitutes may be carriers.
- Patients presenting with other genital ulcerative diseases
Condom use should be demonstrated and promoted.
- Involves entry of the bacteria through abraded skin, followed by attachment of the bacteria to susceptible cells
- Cytotoxin is secreted, which may play a role in epithelial injury and ulcer formation.
- The bacterium contains a fimbrialike protein (flp) operon that encodes proteins that contribute to adherence and pathogenesis.
- Dendritic cells and natural killer cells respond to Haemophilus ducreyi, and this innate host response determines bacterial clearance versus disease progression.
Haemophilus ducreyi (gram-negative rod) thought to be strictly a human pathogen
Commonly Associated Conditions
- Syphilis: Concurrent in 10% of patients
- Herpes simplex virus (HSV) or HIV infection