Patient may have only some of the following symptoms; the abdominal exam may be unrevealing:
- Chills and fever (90%)
- RUQ or epigastric tenderness (70%), with or without cessation of inspiration on palpation (Murphy sign); atypical locations can occur
- Jaundice (60%)
- Hypotension (30%)
- CNS depression (10–20%)
- Palpable nontender gallbladder (Courvoisier sign) rarely
- Signs of underlying pathology, such as chronic liver disease
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