Explore 5-Minute Clinical Consult - view these FREE monographs:
-- The first section of this topic is shown below --
- One of many diseases associated with pathological mineralization and ossification:
- Chondrocalcinosis and pseudogout are characterized by calcium pyrophosphate dihydrate (CPPD) deposition, whereas ankylosing spondylitis, osteoarthritis, and vascular calcification are characterized by hydroxyapatite deposition (1).
- CPPD crystal deposition may cause a progressive degenerative arthritis in numerous joints:
- Primarily affects the elderly
- Usually involves large joints
- Symptom onset is insidious, resulting in symmetric polyarthritis similar to rheumatoid arthritis (RA).
- Definitive CPPD diagnosis requires the presence of CPPD crystals in synovial fluid (2)[A].
- System(s) affected: Endocrine/Metabolic; Musculoskeletal
- Predominant age: 80% of patients >60
- Predominant sex: Male = Female
- Chondrocalcinosis is present in 1:10 adults age 60–75 and 1:3 by >80 ; only a small percentage develop pseudogout (3).
- Advanced age
- Traumatic injury
- Pseudogout often occurs as a complication in patients hospitalized for other medical and surgical illnesses.
Uncommonly seen in familial pattern with autosomal-dominant inheritance (<1% of patients); most cases are sporadic.
Colchicine 0.6 mg b.i.d. may reduce frequency of episodes in recurrent monoarthritic CPPD.
- Arthropathy results from an acute inflammatory reaction to CPPD crystals shed into synovial cavity.
- Physical and chemical changes in aging cartilage favor crystal growth.
Commonly Associated Conditions
- Wilson disease