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Bartter Syndrome

Basics

  • Bartter syndrome and Bartter-like syndrome are a group of rare autosomal recessive, salt-wasting nephropathies characterized by polyuria, hypokalemia, metabolic alkalosis, and normotension with hyperreninemic-hyperaldosteronism (1).
  • Traditionally they have been divided into 2 main disorders according to where the defect is located in the renal tubule. However, more subtypes have been described with genetic classification (2).
  • Bartter (furosemide type) has 5 subtypes, and Gitelman (thiazide type) has 3 subtypes, and there are 3 combinations of the 2 (3).

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