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- Stevens-Johnson Syndrome (SJS) is a severe hypersensitivity reaction, characterized by diffuse bullous lesions, mucocutaneous involvement, and marked constitutional symptoms.
- SJS is often considered to lie on a spectrum between erythema multiforme minor (EM minor) on 1 extreme, and toxic epidermal necrolysis (TEN) on the other, but this classification is controversial. In this schema, SJS is defined as involving >2 mucous membranes and <10% of total body surface area, and TEN as involving >30%, with overlap in between.