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Neonatal cholestasis presents at or shortly after birth with the accumulation of bilirubin, bile acids, and cholesterol in blood and extrahepatic tissues. Neonatal cholestasis most often manifests with conjugated hyperbilirubinemia and jaundice. Any infant who is jaundiced beyond 2 weeks of life warrants further evaluation for neonatal cholestasis.
- Biochemical definition: Serum conjugated bilirubin >2 mg/dL or >15% of the total bilirubin concentration