MEDLINE Journals

    How DMSO, a widely used solvent, affects spinal cord injury.

    Authors
    Turan NN, Akar F, Budak B, et al. 
    Source
    Ann Vasc Surg 2008 Jan; 22(1) :98-105.
    Abstract

    The aim of this experimental study was to investigate whether dimethylsulfoxide (DMSO) has protective effects on spinal cord ischemia-reperfusion (I/R) injury. New Zealand rabbits were enrolled in the study. In addition to the control group, the study group received 0.1 mL/kg DMSO prior to ischemia. Blood samples were taken to obtain nitrite-nitrate levels during the surgical procedure. After neurological evaluation at 24 hr of reperfusion, lumbar spinal cords were removed for electron microscopic evaluation and malondialdehyde and myeloperoxidase measurements. The mean Tarlov score of the DMSO group was higher than that of the control group. Electron microscopic examination was carried out with tissue samples at 24 hr of reperfusion. The DMSO group had better preservation with the electron microscopic scoring compared to the control group. Malondialdehyde and myeloperoxidase levels were decreased in the DMSO group compared to the control group. Nitrite-nitrate levels were also lower in the DMSO group compared to control at 5 and 30 min of reperfusion. This study demonstrates a considerable neuroprotective effect of DMSO on neurological, biochemical, and histopathological analyses during periods of spinal cord I/R injury in rabbits. Although there was a difference between the DMSO and control groups in all measured parameters in our study, this was not statistically significant. DMSO deserves further investigation related with spinal cord ischemia and reperfusion. We should also consider the effect of DMSO when we use it as a solvent or vehicle during experimental I/R models.

    Mesh
    Animals
    Aorta, Abdominal
    Dimethyl Sulfoxide
    Disease Models, Animal
    Free Radical Scavengers
    Ligation
    Malondialdehyde
    Neuroprotective Agents
    Nitrates
    Nitrites
    Peroxidase
    Rabbits
    Reperfusion Injury
    Solvents
    Spinal Cord
    Spinal Cord Ischemia
    Time Factors
    Tyrosine
    Language

    eng

    Pub Type(s)
    Journal Article
    PubMed ID

    18086517

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