MEDLINE Journals

    Prevalence of synthetic cannabinoids in U.S. athletes: initial findings.

    Authors
    Heltsley R, Shelby MK, Crouch DJ, et al. 
    Institution

    Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA.

    Source
    J Anal Toxicol 2012 Oct; 36(8) :588-93.
    Abstract

    A number of synthetic cannabinoids such as JWH-018 and JWH-073 have been incorporated into "spice" products. Despite having labels warning against human consumption, the products are smoked for their cannabinoid-like effects and the extent of their use by athletes has not been adequately described. Urine samples collected from 5,956 athletes were analyzed by high-performance liquid chromatography-tandem mass spectrometry for the presence of JWH-018, JWH-073, and their metabolites. Metabolites of JWH-018 and/or JWH-073 were detected in 4.5% of the samples. Metabolites of JWH-018 and JWH-073, only JWH-018, and only JWH-073 were detected in 50%, 49%, and approximately 1% of positive samples, respectively. In total, JWH-018 metabolites were detected in 99% (50% + 49%) and JWH-073 metabolites were detected in approximately 50% (49% + 1%) of the positive samples. Parent JWH-018, JWH-018-2-OH-indole, and JWH-018-4-OH-indole were not detected in any of the samples. All samples in which JWH-073 metabolites were detected contained JWH-073-N-butanoic acid. Parent JWH-073 and its N-(4-OH-butyl), 4-OH-indole, 5-OH-indole, and 7-OH-indole metabolites were not detected. Given the number of synthetic cannabinoids that have been synthesized, their limited regulation, and the prevalence of JWH-018 and JWH-073 metabolites detected in the athletes, these compounds should remain a priority for anti-doping programs.

    Mesh
    Chromatography, High Pressure Liquid
    Doping in Sports
    Humans
    Indoles
    Naphthalenes
    Receptor, Cannabinoid, CB1
    Sports
    Street Drugs
    Substance Abuse Detection
    Tandem Mass Spectrometry
    United States
    Language

    eng

    Pub Type(s)
    Journal Article
    PubMed ID

    22872465

    Content Manager
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