MEDLINE Journals

    Effect of bismuth subsalicylate on Clostridium difficile colitis in hamsters.

    Authors
    Chang TW, Dong MY, Gorbach SL 
    Institution

    Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111.

    Source
    Rev Infect Dis 1990 Jan-Feb.:S57-8.
    Abstract

    The therapeutic effect of bismuth subsalicylate (BSS, Pepto-Bismol) in Clostridium difficile colitis was studied in golden Syrian hamsters. C. difficile was fed to the hamsters by orogastric intubation 2-3 days after their arrival. Clindamycin (1.5 mg per animal) was given intraperitoneally 4 days later. Twenty-four hours after challenge with clindamycin, animals were given BSS at dosages of 5, 10, and 15 mg twice daily for 5 days by orogastric intubation. Controls included untreated animals and those given 5 mg of vancomycin once daily by intubation. Delay in the time of death was observed in all BSS-treated animals and was statistically significant on days 4-6 in those receiving 15 mg twice daily. Vancomycin produced a greater delay in death than did BSS. Our study suggests that BSS at a dosage of 15 mg twice daily has some therapeutic effect on C. difficile colitis in hamsters.

    Mesh
    Animals
    Bacterial Proteins
    Bacterial Toxins
    Bismuth
    Clindamycin
    Clostridium
    Cricetinae
    Disease Models, Animal
    Enterocolitis, Pseudomembranous
    Feces
    Male
    Mesocricetus
    Organometallic Compounds
    Salicylates
    Vancomycin
    Language

    eng

    Pub Type(s)
    Journal Article
    PubMed ID

    2305177

    Content Manager
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