MEDLINE Journals

    Alkaline phosphatase isoenzymes in rheumatic diseases.

    Authors
    Siede WH, Seiffert UB, Merle S, et al. 
    Institution

    Zentrallaboratorium, Klinikum der J.W. Goethe-Universität, Frankfurt, FRG.

    Source
    Clin Biochem 1989 Apr; 22(2) :121-4.
    Abstract

    Serum alkaline phosphatase isoenzymes were determined quantitatively by electrophoresis on cellulose acetate in 168 patients with rheumatic diseases subgrouped for disease activity. Median values of total alkaline phosphatase and bone isoenzyme activity, as well as frequency of patients showing pathological values, increased gradually and significantly corresponding to disease activity in rheumatoid arthritis and ankylosing spondylitis, from 0% in inactive to 90% in very active forms. Bone isoenzyme was much more sensitive than total alkaline phosphatase in moderate disease activity and was also correlated to the number of involved extravertebral joints and pain in ankylosing spondylitis. No correlation was found with stage or duration of disease, age, sex, and erythrocyte sedimentation rate. Additional to bone isoenzyme, liver isoenzymes were elevated in some patients, but with only a weak correlation with disease activity. The intestinal isoenzymes were always normal. We conclude that quantitative determination of serum alkaline phosphatase bone isoenzyme activity is a major indicator for the assessment of disease activity and therapeutic monitoring in rheumatoid arthritis and ankylosing spondylitis.

    Mesh
    Alkaline Phosphatase
    Arthritis, Rheumatoid
    Bone and Bones
    Female
    Humans
    Isoenzymes
    Liver
    Lupus Erythematosus, Systemic
    Male
    Osteoarthritis
    Spondylitis, Ankylosing
    Language

    eng

    Pub Type(s)
    Journal Article
    PubMed ID

    2720963

    Content Manager
    Related Content

    The clinical significance of serum alkaline phosphatase isoenzymes in locomotor diseases.

    Alkaline phosphatase activity in the serum of patients with rheumatoid arthritis.

    Source and significance of serum alkaline phosphatases in diseases of the locomotor system.

    Bone alkaline phosphatase in rheumatic diseases.

    Increased serum alkaline phosphatase activity in ankylosing spondylitis.

    Reference limits of bone and liver alkaline phosphatase isoenzymes in the serum of healthy subjects according to age and sex as determined by wheat germ lectin affinity electrophoresis.

    Serum gamma-glutamyltransferase and alkaline phosphatase in rheumatoid arthritis.

    Quantitative alkaline phosphatase isoenzyme determination by electrophoresis on cellulose acetate membranes.