MEDLINE Journals

    Miniature axial flow pump for ventricular assistance in children and small adults.

    Kaplon RJ, Oz MC, Kwiatkowski PA, et al. 
    J Thorac Cardiovasc Surg 1996 Jan; 111(1) :13-8.

    We investigated the efficacy of the Jarvik 2000 intraventricular assist device (Jarvik Research, Inc., New York, N.Y.) in an ovine model. The device is an axial flow pump measuring 1.8 cm in diameter by 5 cm long, has a displacement volume of 12 ml, and can deliver flow from 2 to 7 L/min. Seven devices were implanted through a left thoracotomy into the left ventricle with an outflow graft to the descending aorta. Animals were treated with warfarin sodium and aspirin to maintain prothrombin times approximately 1.5 times control. Animals were followed up for 3 to 123 days. Two animals died of operative complications at days 3 and 5. One device failed at 58 days because of thrombus formation at the inflow side of the impeller. The remaining four animals were killed at days 19, 42, 42, and 123, respectively, because of broken electric power cables. Hematocrit values rose significantly higher than preoperative levels (22.8% +/- 3.8% to 30.5% +/- 3.4%); premortem elevations of values higher than baseline values of plasma free hemoglobin (10.4 +/- 7.8 mg/dl to 17.1 +/- 7.4 mg/dl) and lactate dehydrogenase (391.5 +/- 113.7 units/L to 771.2 +/- 370.8 units/L) were statistically insignificant. Serum creatinine and bilirubin levels were normal. No end-organ dysfunction arising from long-term support was evident clinically or at postmortem examination, nor was there any evidence of embolism or damage to intracardiac structures. We found the Jarvik 2000 intraventricular assist device to be easily implantable, safe, nonhemolytic, and able to provide physiologic flow with power requirements under 10 watts.

    Blood Vessel Prosthesis
    Coronary Circulation
    Electric Power Supplies
    Equipment Design
    Heart-Assist Devices
    Polyethylene Terephthalates


    Pub Type(s)
    Journal Article
    PubMed ID


    Content Manager
    Related Content

    The Jarvik 2000 Oxford system: increasing the scope of mechanical circulatory support.

    In vivo evaluation of an intraventricular electric axial flow pump for left ventricular assistance.

    More than 1 year continuous operation of a centrifugal pump with a magnetically suspended impeller.

    Five month survival in a calf supported with an intraventricular axial flow blood pump.

    A miniature implantable axial flow ventricular assist device.

    Miniaturized HIA microdiagonal pump as left ventricular assist device in a sheep model.

    Development of an implantable small right ventricular assist device.

    Survival for up to six months in calves supported with an implantable axial flow ventricular assist device.