MEDLINE Journals

    Animal models for transdermal drug delivery.

    Authors
    Panchagnula R, Stemmer K, Ritschel WA 
    Institution

    Division of Pharmaceutics and Drug Delivery Systems, University of Cincinnati Medical Center, OH, USA.

    Source
    Methods Find Exp Clin Pharmacol 1997 Jun; 19(5) :335-41.
    Abstract

    The purpose of this investigation was to compare the permeation characteristics of two different compounds (extremely polar and nonpolar), i.e., tritium-labeled water (W) and 14C-labeled 7-hydroxycoumarin (7-OHC), among 16 different species, including human skin. Snake skin exhibited highest permeability for both W and 7-OHC. Permeability and lag time values of W and 7-OHC across Brattleboro rat and hairless guinea pig are very close to human skin. Skin thickness in micrometers (full thickness, epidermis and stratum corneum, and stratum corneum), and number of hair follicles present in each cm2 were determined for each species. There was no relationship between number of hair follicles and permeability values for both W and 7-OHC. The skin thickness (full) was related to the relative permeability values of W, whereas for 7-OHC it was not.

    Mesh
    Administration, Cutaneous
    Animals
    Cattle
    Cricetinae
    Dogs
    Drug Delivery Systems
    Guinea Pigs
    Hair Follicle
    Haplorhini
    Humans
    Mice
    Mice, Nude
    Rabbits
    Rats
    Rats, Brattleboro
    Rats, Sprague-Dawley
    Sheep
    Skin
    Skin Absorption
    Snakes
    Species Specificity
    Swine
    Umbelliferones
    Water
    Language

    eng

    Pub Type(s)
    Comparative Study Journal Article
    PubMed ID

    9379782

    Content Manager
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