MEDLINE Journals

    A new silver sulfadiazine water soluble gel.

    Gear AJ, Hellewell TB, Wright HR, et al. 
    Burns 1997 Aug; 23(5) :387-91.

    Silver sulfadiazine is the most commonly used topical antibacterial agent for the treatment of burn wounds. It has many clinical advantages, including a broad spectrum of antimicrobial activity, low toxicity, and minimal pain on application. The current formulation of silver sulfadiazine contains a lipid soluble carrier, polypropylene glycol, that has certain disadvantages, including pseudo-eschar formation and the need for twice daily application. The purpose of this investigation was to describe a new formulation of silver sulfadiazine in a water soluble gel, poloxamer 188. The antibacterial activity of this new gel has been compared to that of the commercially available silver sulfadiazine cream by in vitro and in vivo testing. The results of the in vitro antibacterial testing of these two different agents demonstrated the superiority of the new gel formulation. In experimental wounds, the antibacterial activity of the gel and the commercially available silver sulfadiazine cream were not significantly different when applied once a day. The antibacterial activity of the gel when applied once a day was comparable to that encountered by twice daily applications of the silver sulfadiazine cream by experimental wounds. The major advantage of this gel was its ease of application and removal that is attributed to its water solubility.

    Administration, Topical
    Anti-Infective Agents, Local
    Chemistry, Pharmaceutical
    Disease Models, Animal
    Drug Delivery Systems
    Drug Evaluation
    Rats, Sprague-Dawley
    Silver Sulfadiazine
    Skin Diseases, Bacterial
    Staphylococcal Infections
    Staphylococcus aureus
    Wound Infection


    Pub Type(s)
    Comparative Study Journal Article Research Support, Non-U.S. Gov't
    PubMed ID


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