MEDLINE Journals

    Neural crest development: the interplay between morphogenesis and cell differentiation.

    Authors
    Erickson CA, Reedy MV 
    Source
    Curr Top Dev Biol 1998.:177-209.
    Abstract

    The final pattern of tissues established during embryogenesis reflects the outcome of two developmental processes: differentiation and morphogenesis. Avian neural crest cells are an excellent system in which to study this interaction. In the first phase of neural crest cell migration, neural crest cells separate from the neural epithelium via an epithelial-mesenchymal transformation. We present three models to account for this process: (1) separation by asymmetric mitosis, (2) separation by generating tractional force in order to rupture cell adhesions and (3) loss of expression or function of cell-cell adhesion molecules that keep the presumptive neural crest cells tethered to the neural epithelium. Evidence is presented that the segregation of the neural crest lineage apart from the neural epithelium is caused by the epithelial-mesenchymal transformation. Once they have detached from the neural tube, neural crest cells take two pathways in the trunk of the chick embryo: (1) the ventral path between the neural tube and somite, where neural crest cells give rise to neurons and glial cells of the peripheral nervous systems, and (2) the dorsolateral path between the ectoderm and dermamyotome of the somite, where they differentiate into pigment cells of the skin. We present data to suggest that the migration and differentiation along the ventral path is controlled primarily by environmental cues, which we refer to as the environment-directed model of neural crest morphogenesis. Conversely, only melanoblasts can migrate into the dorsolateral space, and the ability to invade that path is dependent upon their early specification as melanoblasts. We call this the phenotype-directed model for neural crest cell migration and suggest that this latter model for the positioning of neural crest derivatives in the embryo may be more common than previously suspected. These observations invite a re-examination of patterning of other crest derivates, which previously were believed to be controlled by environmental cues.

    Mesh
    Animals
    Body Patterning
    Cell Differentiation
    Cell Movement
    Chick Embryo
    Ectoderm
    Epithelium
    Melanocytes
    Mesoderm
    Mitosis
    Models, Biological
    Morphogenesis
    Neural Crest
    Somites
    Language

    eng

    Pub Type(s)
    Journal Article Research Support, U.S. Gov't, P.H.S. Review
    PubMed ID

    9673851

    Content Manager
    Related Content

    The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube.

    Hyperpigmentation in the Silkie fowl correlates with abnormal migration of fate-restricted melanoblasts and loss of environmental barrier molecules.

    Avian neural crest cells can migrate in the dorsolateral path only if they are specified as melanocytes.

    Specification and migration of melanoblasts at the vagal level and in hyperpigmented Silkie chickens.

    Descriptive and experimental analysis of the dispersion of neural crest cells along the dorsolateral path and their entry into ectoderm in the chick embryo.

    The role of Wnt signalling in the development of somites and neural crest.

    Sacral neural crest cell migration to the gut is dependent upon the migratory environment and not cell-autonomous migratory properties.

    Long-distance cue from emerging dermis stimulates neural crest melanoblast migration.