| By Topic Neoplasms Androgen deprivation therapy associated with increased risk of fracture, DM, CVD death Annual mammography starting at 40 doesn't lower breast CA mortality Antioxidants don't prevent colorectal cancer Aspirin prevents colon cancer Cancer risk reduced with vitamin D/calcium supplementation Cancer trials not generalizable to real world Chewing gum hastens bowel motility and shortens hospital stay after colorectal surgery Clinical rule to diagnose PCOS more accurately Colon cancer screening may be beneficial for Lynch syndrome Colon CA unlikely if unexplained anemia but ferritin >100 ng/mL Colonoscopy interval of at least 5 years is safe Combined ultrasound + mammogram for high-risk women increases cancer yield CT colonography detects 85% of large polyps in patients at increased risk of colon cancer CT colonography detects 90% of large polyps under optimal conditions CT colonography less accurate with small polyps CT colonography similar to colonoscopy at detecting advanced lesions CT finds early lung Ca but carries risk (PLuSS) Diet high in vegetables, fruit and fiber/low in fat does not reduce risk of recurrent breast CA Erythropoiesis-stimulating agents increase risk of VTE/death in CA patients Erythropoiesis stimulation increases death risk in cancer patients Esophageal cancer occurs in 7/1000 per year Fecal DNA testing = Hemoccult Sensa for colon cancer screening Fecal immunochemical testing more sensitive than guaiac testing Folic acid does not reduce risk of colorectal adenomas Guideline: Mammography optional in women 40-49 Harms outweigh benefits of aspirin/NSAID for colon cancer prevention Hep C infection increases risk of non-Hodgkin lymphoma High false positive rate in repeated, multimodal screening for cancers (PLCO) Hormones + radiation decrease mortality compared with radiation in prostate cancer HPV DNA screening detects CIN3 and cancer earlier HPV screening more accurate than Pap (CCCaST) HPV testing accurate to rule out residual CIN HRT associated with increased risk of ovarian cancer Incidental findings common on brain MRI in adults Increased health risk in long-term survivors of childhood cancer Lenalidomide effective for relapsed multiple myeloma Liquid-based = conventional cervical cytology Long-term vitamins do not prevent lung cancer Low-cost manual liquid cytology feasible Low hCG in peri- and postmenopausal women normal Low risk of residual CIN after treatment if HPV negative Lubricant does not interfere with Pap smears Mammography identifies many women who will not benefit from treatment Melanoma risk 0.7% in congenital melanocytic nevi Methylphenidate, hematopoietic agents helpful in cancer-related fatigue Mifepristone effective tx for bleeding due to fibroids No increased CVD, breast CA risk (or fracture prevention) 3 yrs after HRT No stirrups preferred for pelvic exam Obesity does not predict survival after radical prostatectomy OCs associated with long-term reduction in ovarian cancer risk OCs not associated with overall cancer risk Pedigree identifies hereditary breast cancer syndromes Postcoital bleeding of limited use in determining cervical cancer risk Preterm birth increased after treatment for CIN Prophylactic salpingo-oophorectomy reduces ovarian cancer risk Quadrivalent HPV vaccine prevents CIN 2/3, anogenital warts (FUTURE II) Quality of life varies after different prostate cancer treatments Raloxifene and tamoxifen equally effective in reducing breast CA risk Raloxifene decreases breast CA risk, no effect on CVD risk (RUTH) Selective use of FNAB is a good option for small thyroid nodule Sentinel node biopsy = less lymphedema, better QOL (ALMANAC) Spiral CT detects early lung cancer, but screening use is premature Survivors of childhood acute lymphoblastic leukemia at long-term increased cancer risk Sustained effects of false-positive mammogram results Switching to digital mammography for all is too costly Transdermal testosterone does not improve libido in female cancer survivors Ureteral stents not effective, increase symptoms USPSTF: No colon cancer screening after age 75 years USPSTF: No PSA screening in men 75 years and older Uterine-artery embolization reasonable alternative to surgery for fibroids VTE: Up to 10% with unexplained embolus will have cancer Yield for CRC screening: colonoscopy > flex sig >> FOBT
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