| By Topic Respiratory 3 days equal to 5 days of oral steroids for acute asthma in children AAP Practice Guideline: Delaying feeding does not prevent atopy Allergic rhinitis associated with increased risk of bronchial hyperreactivity (ECRHS) Antibiotics and nasal steroids of little/no benefit for acute sinusitis Antibiotics for URIs reduce complications (but not enough to matter) Antibiotics in first year of life associated with later asthma Antibiotics slightly effective for purulent rhinitis Anticholinergics of greater benefit in COPD treatment As needed steroid + beta-agonist works well in mild persistent asthma Azithromycin at least as effective as doxycycline for PID BNP misleading in patients with a history of HF Bosentan ineffective in idiopathic pulmonary fibrosis (BUILD-1) Breastfeeding does not decrease asthma/allergy (PROBIT) Bronchial thermoplasty somewhat effective for moderate to severe adult asthma Chest PT not effective for kids with pneumonia Children and GERD: pneumonia with acid suppression Clinical factors predict severe CAP in adults COPD -- combo therapy improves symptoms but doesn't decrease exacerbations Corticosteroids, selective use of antibiotics and NPPV for COPD exacerbations Corticosteroids benefit patients with moderate to severe COPD CPAP and NIPPV no better than O2 in acute pulmonary edema (3CPO) CPAP associated with decreased CV risk CT finds early lung Ca but carries risk (PLuSS) D-dimer can identify high-risk group for extended anticoagulation (PROLONG) Dexamethasone + epinephrine more effective for bronchiolitis Dexamethasone not effective for bronchiolitis Early switch to PO effective for severe CAP Eradicating mold improves symptoms but not PFTs Esomeprazole doesn't improve asthma symptoms Fixed-dose, subcutaneous, unfractionated heparin effective for VTE Fluoroquinolones = beta-lactam for acute bacterial sinusitis Fluticasone + salmeterol reduce mortality in COPD Guideline for Medications in CF Guidelines for COPD (ACP) Guidelines for managing VTE (AAFP, ACP) Guidelines for the clinical diagnosis of VTE (AAFP, ACP) Hand washing programs prevent GI and respiratory infections Helium-oxygen improves exercise tolerance in pts with COPD Idraparinux effective for DVT but not for PE Incorrect choice of antibiotic doesn't affect outcome of CAP Influenza vaccination during pregnancy is effective Inhaled anticholinergics associated with increased risk of CVD in COPD Inhaled steroids for COPD associated with increased risk of pneumonia In-hospital PPI use associated with hospital-acquired pneumonia Latent TB high in patients from sub-Saharan Africa and Southeast Asia Live attenuated nasal flu vaccine safe, effective for ages 1 to 5 Long-term vitamins do not prevent lung cancer Low risk of DVT after knee arthroscopy Many patients using warfarin also take aspirin Maybe kids with mild persistent asthma don't need daily steroids Methylprednisolone improves outcomes in ARDS Montelukast+salmeterol inferior to steroids+salmeterol in moderate asthma Montelukast = fluticasone+ salmeterol for mild persistent asthma Montelukast alone ineffective for allergic rhinitis Montelukast ameliorates acute asthma attack in children Morphine improves chronic, intractable cough Multidetector CT accurate for PE, but requires clinical context Naproxen effective for cold symptoms including cough reduction No fewer allergies when solid foods are started after 6 months old NT-BNP reduces cost and rehospitalization rates in dyspneic patients O2 not helpful in overall QOL in COPD with exertional hypoxia Only 1 in every 3 children with eczema will develop asthma Optimal dosing for thromboprophylaxis in medical inpatients Oral = IV prednisolone for COPD exacerbation Oral steroids effective for nasal polyps Pneumonia: 3 days of antibiotics for uncomplicated course Pneumonia can be treated with 3 to 5 days of abx PPIs not helpful for GERD-related chronic laryngitis Probiotics safe, minimally effective in newborns Procalcitonin test can reduce antibiotic use in COPD Pulmonary Embolism (PE) Severity Index predicts low risk PE patients Rapid antigen test reduces antibiotic use in adult sore throat Rapid influenza tests reduce ER testing in kids, little else Saline irrigation more effective than spray for nasal symptoms Salmeterol + fluticasone better than tiotropium in COPD (INSPIRE) Second-line antibiotics more effective than first-line in AECB Short-course antibiotics effective for acute exacerbation of COPD Single dose azithromycin effective for cholera Single dose of honey effective for cough in kids Spiral CT detects early lung cancer, but screening use is premature Stuttering withdrawal of life support better for surviving family Sublingual allergen tablet reduces symptoms of grass allergy Summary of GOLD guideline for COPD URI: Patients want explanation, not prescription VTE: Up to 10% with unexplained embolus will have cancer
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