MEDLINE Journals

    The expression of E-cadherin-catenin complex in adenoid cystic carcinoma of salivary glands.


    Zhang ZY, Wu YQ, Zhang WG, et al. 


    Chin J Dent Res 2000 Nov; 3(3) :36-9.


    The aim of this study was to investigate the expression of the E-cadherin-catenin (E-cad-cat) complex in human salivary adenoid cystic carcinoma (ACC) and determine the effects of E-cad-cat expression on tumor differentiation, metastasis, and invasion, as well as its clinical significance.
    The expression of adhesion molecules, which included E-cadherin, alpha-catenin, and beta-catenin, on 10 cases of normal salivary glands, and 50 cases of human salivary ACC were investigated by immunohistochemistry.
    Strong and stable expression of E-cad-cat complex showed in normal salivary glands tissues. However, weaker expression and even complete absence, of the positive signals were shown on all ACC cases. Coexpression of E-cad-cat were detected in 29 (58%) of the 50 ACC specimens. Positive staining of E-cad-cat complex were detected in 7 (39%) of the 18 ACC primary sites that had aggressive phenotype of nerve and vasculature.
    Strong positive signals of E-cad-cat complex are shown in normal salivary glands, and the down-regulated expression were observed in ACC cases. The expression of E-cad-cat complex is associated with a more aggressive phenotype on nerve and vasculature. No association with various histopathologic subtypes was found. However, absent or low E-cad expression was observed more frequently in solid carcinomas than in cribriform or tubular carcinomas. Down-regulation of E-cad-cat complex may be associated with canceration of normal salivary glands. The expression levels of E-cad-cat were positively correlated to the differentiation of ACC tumor cells.


    Antibodies, Monoclonal
    Carcinoma, Adenoid Cystic
    Cell Differentiation
    Cell Transformation, Neoplastic
    Coloring Agents
    Cytoskeletal Proteins
    Gene Expression Regulation, Neoplastic
    Immunoenzyme Techniques
    Neoplasm Invasiveness
    Salivary Gland Neoplasms
    Salivary Glands
    Statistics as Topic
    alpha Catenin
    beta Catenin



    Pub Type(s)

    Journal Article Research Support, Non-U.S. Gov't

    PubMed ID


    Content Manager
    Related Content

    [The expression of E-cadherin-catenin complex in human salivary adenoid cystic carcinoma]

    Ultrastructural localization of E-cadherin and alpha-/beta-catenin in adenoid cystic carcinoma.

    Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma.

    [Expression and significance of E-cadherin in adenoid cystic carcinoma of the salivary glands].

    Expression of beta-catenin, E-cadherin and cyclin D1 in adenoid cystic carcinoma of the salivary gland.

    Reduced E-cadherin expression correlates with unfavorable prognosis in adenoid cystic carcinoma of salivary glands of the oral cavity.

    Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome.

    Association of E-cadherin and beta-catenin with metastasis in nasopharyngeal carcinoma.