MEDLINE Journals

    The expression of E-cadherin-catenin complex in adenoid cystic carcinoma of salivary glands.

    Authors

    Zhang ZY, Wu YQ, Zhang WG, et al. 

    Institution

    School of Stomatology, Shanghai Second Medical University (SSMU), 639 Zhizaoju Road, Shanghai 2000111, P. R. China.

    Source

    Chin J Dent Res 2000 Nov; 3(3) :36-9.

    Abstract

    OBJECTIVE
    The aim of this study was to investigate the expression of the E-cadherin-catenin (E-cad-cat) complex in human salivary adenoid cystic carcinoma (ACC) and determine the effects of E-cad-cat expression on tumor differentiation, metastasis, and invasion, as well as its clinical significance.
    METHODS
    The expression of adhesion molecules, which included E-cadherin, alpha-catenin, and beta-catenin, on 10 cases of normal salivary glands, and 50 cases of human salivary ACC were investigated by immunohistochemistry.
    RESULTS
    Strong and stable expression of E-cad-cat complex showed in normal salivary glands tissues. However, weaker expression and even complete absence, of the positive signals were shown on all ACC cases. Coexpression of E-cad-cat were detected in 29 (58%) of the 50 ACC specimens. Positive staining of E-cad-cat complex were detected in 7 (39%) of the 18 ACC primary sites that had aggressive phenotype of nerve and vasculature.
    CONCLUSION
    Strong positive signals of E-cad-cat complex are shown in normal salivary glands, and the down-regulated expression were observed in ACC cases. The expression of E-cad-cat complex is associated with a more aggressive phenotype on nerve and vasculature. No association with various histopathologic subtypes was found. However, absent or low E-cad expression was observed more frequently in solid carcinomas than in cribriform or tubular carcinomas. Down-regulation of E-cad-cat complex may be associated with canceration of normal salivary glands. The expression levels of E-cad-cat were positively correlated to the differentiation of ACC tumor cells.

    Mesh

    Antibodies, Monoclonal
    Cadherins
    Carcinoma, Adenoid Cystic
    Cell Differentiation
    Cell Transformation, Neoplastic
    Coloring Agents
    Cytoskeletal Proteins
    Down-Regulation
    Gene Expression Regulation, Neoplastic
    Humans
    Immunoenzyme Techniques
    Neoplasm Invasiveness
    Phenotype
    Salivary Gland Neoplasms
    Salivary Glands
    Statistics as Topic
    Trans-Activators
    alpha Catenin
    beta Catenin

    Language

    eng

    Pub Type(s)

    Journal Article Research Support, Non-U.S. Gov't

    PubMed ID

    11314533

    Content Manager
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