MEDLINE Journals

    Neoflavonoids and related constituents from Nepalese propolis and their nitric oxide production inhibitory activity.

    Authors

    Awale S, Shrestha SP, Tezuka Y, et al. 

    Institution

    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.

    Source

    J Nat Prod 2005 Jun; 68(6) :858-64.

    Abstract

    A methanolic extract of Nepalese propolis yielded 10 new open-chain neoflavonoids (1-10), a new chalcone (11), and eight previously reported compounds (12-19). Their structures were determined on the basis of spectroscopic data and chemical conversion. The isolated compounds other than 5, 8, and 16 showed dose-dependent inhibitory activities on nitric oxide production in lipopolysaccharide-activated macrophage-like J774.1 cells and were more active than a positive control, N(G)-monomethyl-L-arginine (IC(50), 27.1 microM). The most potent activities, of 6 and 7 (IC(50), 0.5 microM), were greater than another positive control, caffeic acid phenethyl ester (IC(50), 4.8 microM).

    Mesh

    Caffeic Acids
    Flavonoids
    Inhibitory Concentration 50
    Lipopolysaccharides
    Macrophages
    Molecular Structure
    Nepal
    Nitric Oxide
    Nuclear Magnetic Resonance, Biomolecular
    Phenylethyl Alcohol
    Propolis
    omega-N-Methylarginine

    Language

    eng

    Pub Type(s)

    Journal Article Research Support, Non-U.S. Gov't

    PubMed ID

    15974608

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