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    Neoflavonoids and related constituents from Nepalese propolis and their nitric oxide production inhibitory activity.


    Awale S, Shrestha SP, Tezuka Y, et al. 


    J Nat Prod 2005 Jun; 68(6) :858-64.


    A methanolic extract of Nepalese propolis yielded 10 new open-chain neoflavonoids (1-10), a new chalcone (11), and eight previously reported compounds (12-19). Their structures were determined on the basis of spectroscopic data and chemical conversion. The isolated compounds other than 5, 8, and 16 showed dose-dependent inhibitory activities on nitric oxide production in lipopolysaccharide-activated macrophage-like J774.1 cells and were more active than a positive control, N(G)-monomethyl-L-arginine (IC(50), 27.1 microM). The most potent activities, of 6 and 7 (IC(50), 0.5 microM), were greater than another positive control, caffeic acid phenethyl ester (IC(50), 4.8 microM).


    Caffeic Acids
    Inhibitory Concentration 50
    Molecular Structure
    Nitric Oxide
    Nuclear Magnetic Resonance, Biomolecular
    Phenylethyl Alcohol



    Pub Type(s)

    Journal Article Research Support, Non-U.S. Gov't

    PubMed ID


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