MEDLINE Journals

    Acute failure of the transplanted kidney--pathophysiology, diagnosis and prevention.

    Authors

    Wiecek A, Nowicki M, Kokot F, et al. 

    Institution

    Department of Nephrology, Silesian University School of Medicine, Katowice, Poland.

    Source

    Ann Transplant 1996; 1(4) :5-9.

    Abstract

    Acute failure of the transplanted kidney is a major problem in the early posttransplant phase and is recognized as a major cause of graft loss. Early renal transplant dysfunction is mainly due to ischemic damage (acute tubular necrosis), rejection, infection, and cyclosporin A toxicity. Less common causes include bleeding, ureteral obstruction, urinary leak, venous thrombosis, and stenosis or occlusion of the renal transplant artery. Recent advances in both invasive (renal biopsy) and non-invasive (imaging and biochemical) techniques have improved specificity and sensitivity of the diagnosis of the acute renal failure. Several procedures which aim to prevent the kidney transplant failure have recently been introduced. Although they were shown to reduce the incidence of early allograft failure, their influence on the long-term graft survival remains to be proven.

    Mesh

    Acute Disease
    Animals
    Communicable Diseases
    Cyclosporine
    Graft Rejection
    Humans
    Immunosuppressive Agents
    Kidney Transplantation
    Kidney Tubular Necrosis, Acute
    Postoperative Complications
    Treatment Failure

    Language

    eng

    Pub Type(s)

    Journal Article Review

    PubMed ID

    9869899

    Content Manager
    Related Content

    Comparison of fine-needle aspiration biopsy, Doppler ultrasound, and radionuclide scintigraphy in the diagnosis of acute allograft dysfunction in renal transplant recipients: sensitivity, specificity, and cost analysis.

    Doppler and color Doppler imaging in acute transplant failure.

    Use of intrarenal needle manometry in acute renal dysfunction following renal transplantation.

    Post transplant acute renal failure: a review.

    Duplex Doppler ultrasonography in the dysfunction of early renal allografts: correlation with renal histopathology.

    Serum and urine IL-6 and TNF-alpha in renal transplant recipients with graft dysfunction.

    Withdrawal of cyclosporine in renal transplant recipients with acute tubular necrosis improves renal function.

    Results of 3-year phase III clinical trials with daclizumab prophylaxis for prevention of acute rejection after renal transplantation.