MEDLINE Journals

    Acute failure of the transplanted kidney--pathophysiology, diagnosis and prevention.


    Wiecek A, Nowicki M, Kokot F, et al. 


    Ann Transplant 1996; 1(4) :5-9.


    Acute failure of the transplanted kidney is a major problem in the early posttransplant phase and is recognized as a major cause of graft loss. Early renal transplant dysfunction is mainly due to ischemic damage (acute tubular necrosis), rejection, infection, and cyclosporin A toxicity. Less common causes include bleeding, ureteral obstruction, urinary leak, venous thrombosis, and stenosis or occlusion of the renal transplant artery. Recent advances in both invasive (renal biopsy) and non-invasive (imaging and biochemical) techniques have improved specificity and sensitivity of the diagnosis of the acute renal failure. Several procedures which aim to prevent the kidney transplant failure have recently been introduced. Although they were shown to reduce the incidence of early allograft failure, their influence on the long-term graft survival remains to be proven.


    Acute Disease
    Communicable Diseases
    Graft Rejection
    Immunosuppressive Agents
    Kidney Transplantation
    Kidney Tubular Necrosis, Acute
    Postoperative Complications
    Treatment Failure



    Pub Type(s)

    Journal Article Review

    PubMed ID


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