Unbound MEDLINE

Physiological rationale for suppression of fever.

Abstract

Two critical assumptions are made when prescribing antipyretic therapy. One is that fever is, at least in part, noxious, and the other is that suppression of fever will reduce, if not eliminate, the noxious effects of fever. At present, neither assumption has been validated experimentally.

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    • Authors

    Mackowiak PA

    Institution

    Medical Care Clinical Center, Veterans Affairs Maryland Health Care System, and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Philip.Mackowiak@med.va.gov

    Source

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 31 Suppl 5: 2000 Oct pg S185-9

    MeSH

    Analgesics, Non-Narcotic
    Animals
    Biological Evolution
    Clinical Trials as Topic
    Cytokines
    Fever
    Humans
    Reproducibility of Results

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    11113022