Unbound MEDLINE

Serial electrocardiographic changes as a predictor of cardiovascular toxicity in acute tricyclic antidepressant overdose.

Abstract

Tricyclic antidepressant agents continue to be a leading cause of significant morbidity and mortality in reported poisonings involving pharmaceutical agents. Although the history and physical examination play an important role in the assessment of patients with tricyclic antidepressant overdose, the presence of anticholinergic features on examination cannot predict the severity of the overdose. Several clinical variables, in particular electrocardiographic (ECG) changes, have been proposed as a guide to determine the severity of the tricyclic antidepressant poisoning. The authors describe a patient with tricyclic antidepressant overdose who presented with altered mental status and whose serial ECG changes played a significant role in diagnosing and predicting the impending cardiovascular toxicity. The role of ECG changes in making the diagnosis and assessing the severity of the tricyclic antidepressant overdose is reviewed.

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  • Publisher Full Text
  • Authors

    Singh N, Singh HK, Khan IA

    Institution

    Department of Internal Medicine, Long Island College Hospital, Brooklyn, NY, USA.

    Source

    American journal of therapeutics 9:1 pg 75-9

    MeSH

    Amitriptyline
    Antidepressive Agents, Tricyclic
    Arrhythmias, Cardiac
    Bipolar Disorder
    Electrocardiography
    Heart Conduction System
    Humans
    Male
    Middle Aged
    Overdose

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    11782822