Abstract

Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV-VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations.

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Publisher Full Text

Authors

Kenawy el-R, Bowlin GL, Mansfield K, Layman J, Simpson DG, Sanders EH, Wnek GE

Institution

Department of Chemical Engineering, Virginia Commonwealth University, Richmond, VA 23298, USA.

Source

Journal of controlled release : official journal of the Controlled Release Society 81:1-2 2002 May 17 pg 57-64

MeSH

Anti-Bacterial Agents
Chemistry, Pharmaceutical
Drug Carriers
Drug Delivery Systems
Elasticity
Lactic Acid
Macromolecular Substances
Polymers
Polyvinyls
Static Electricity
Tetracycline
Viscosity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

11992678