Abstract

Standard lipoprotein measurements may not adequately reflect the increased atherogenic risk found in patients with abnormalities in lipoprotein particle size and subfraction distribution such as disproportionate amounts of small, dense low-density lipoprotein particles, small high-density lipoprotein particles, or large very-low-density lipoprotein particles. Measurement or anticipation of patients most susceptible to lipoprotein subfraction abnormalities may influence therapeutic choices for the optimal management of dyslipidemia. Previously, the ADvicor Vs. Other Cholesterol-modulating Agents Trial Evaluation demonstrated that niacin extended release/lovastatin provided greater global improvement in lipid parameters such as low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, lipoprotein (a), apolipoprotein B, and apolipoprotein A-I blood levels compared with atorvastatin and simvastatin monotherapies. In this report, niacin extended release/lovastatin was also more effective than atorvastatin and simvastatin monotherapies in reducing small, dense low-density lipoprotein particles and improving low-density lipoprotein phenotype pattern at relative starting doses, and was more effective in increasing the proportion of high-density lipoprotein in the potentially cardioprotective 2b subclass at all doses.

Links

Publisher Full Text

Authors

Bays HE, McGovern ME

Institution

Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY 40213, USA.

Source

Preventive cardiology 6:4 2003 pg 179-88

MeSH

Aged
Cholesterol, HDL
Cholesterol, LDL
Drug Combinations
Female
Heptanoic Acids
Humans
Hyperlipidemias
Hypolipidemic Agents
Lipoproteins
Lovastatin
Male
Middle Aged
Niacin
Particle Size
Pyrroles
Randomized Controlled Trials as Topic
Simvastatin

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14605511