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Effect of pH on the in vitro activities of amphotericin B, itraconazole, and flucytosine against Aspergillus isolates.

Abstract

The in vitro susceptibilities of 21 Aspergillus isolates were tested against three antifungal agents in RPMI 1640 and yeast nitrogen base at pH 5.0 and 7.0 by a broth microdilution format of the NCCLS method. The MICs of amphotericin B and itraconazole were higher, while those of flucytosine were lower, at pH 5.0 than at pH 7.0. The poor correlation between in vitro results and clinical outcome could be due to a difference in pH between the in vitro susceptibility test and at the site of infection.

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  • Authors

    Te Dorsthorst DT, Mouton JW, van den Beukel CJ, van der Lee HA, Meis JF, Verweij PE

    Institution

    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

    Source

    Antimicrobial agents and chemotherapy 48:8 2004 Aug pg 3147-50

    MeSH

    Amphotericin B
    Antifungal Agents
    Aspergillosis
    Aspergillus
    Candida
    Flucytosine
    Humans
    Hydrogen-Ion Concentration
    Itraconazole
    Microbial Sensitivity Tests

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15273136