Recent advances in antidepressant drugs.


Tricyclic antidepressants (TCAs) are notorious for a number of disadvantages, but particularly for an array of side-effects that leads to poor compliance, and also for a dangerous toxicity in overdose. Lofepramine is a new tricyclic that seems safer. Selective serotonin reuptake inhibitors (SSRIs) are more limited in their actions. Side-effects include nausea and insomnia, but on the whole the side-effect profile is an improvement on the TCAs. A miscellaneous group of novel antidepressants includes mianserin and trazodone (which both produce drowsiness) and viloxazine (which causes nausea). The reversible inhibitors of monoamine oxidase A (RIMAs) are a group of drugs that, by producing inhibition selectively of monoamine oxidase A (MOA-A), still allow metabolism of tyramine by MAO-B. Moclobemide is a RIMA that has proved itself to be very effective in severe depressive illness. It is remarkably safe and has an exceptionally low incidence of side-effects. It may be expected to be associated with a high acceptability in depressed patients.


Priest RG

Academic Department of Psychiatry, St Mary's Hospital Medical School, London, UK.

Baldwin DS

Bullock T

Kibel D

Smeyatsky N

Steinert J


South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Suppl: 1992 Jun 6 pg 1-4


Antidepressive Agents
Antidepressive Agents, Tricyclic
Monoamine Oxidase Inhibitors
Serotonin Antagonists

Pub Type(s)

Journal Article



PubMed ID