TY - JOUR T1 - CAPweb: a bioinformatics CGH array Analysis Platform. AU - Liva,Stéphane, AU - Hupé,Philippe, AU - Neuvial,Pierre, AU - Brito,Isabel, AU - Viara,Eric, AU - La Rosa,Philippe, AU - Barillot,Emmanuel, PY - 2006/7/18/pubmed PY - 2006/8/30/medline PY - 2006/7/18/entrez SP - W477 EP - 81 JF - Nucleic acids research JO - Nucleic Acids Res VL - 34 IS - Web Server issue N2 - Assessing variations in DNA copy number is crucial for understanding constitutional or somatic diseases, particularly cancers. The recently developed array-CGH (comparative genomic hybridization) technology allows this to be investigated at the genomic level. We report the availability of a web tool for analysing array-CGH data. CAPweb (CGH array Analysis Platform on the Web) is intended as a user-friendly tool enabling biologists to completely analyse CGH arrays from the raw data to the visualization and biological interpretation. The user typically performs the following bioinformatics steps of a CGH array project within CAPweb: the secure upload of the results of CGH array image analysis and of the array annotation (genomic position of the probes); first level analysis of each array, including automatic normalization of the data (for correcting experimental biases), breakpoint detection and status assignment (gain, loss or normal); validation or deletion of the analysis based on a summary report and quality criteria; visualization and biological analysis of the genomic profiles and results through a user-friendly interface. CAPweb is accessible at http://bioinfo.curie.fr/CAPweb. SN - 1362-4962 UR - https://www.unboundmedicine.com/medline/citation/16845053/CAPweb:_a_bioinformatics_CGH_array_Analysis_Platform_ L2 - https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkl215 DB - PRIME DP - Unbound Medicine ER -