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Synthesis and characterization of norfloxacin-transition metal complexes (group 11, IB): spectroscopic, thermal, kinetic measurements and biological activity.

Abstract

The investigation of the new structures of Ag(I), Cu(II) and Au(III) complexes, [Ag(2)(Nor)(2)](NO(3))(2), [Cu(Nor)(2)(H(2)O)(2)]SO(4).5H(2)O and [Au(Nor)(2) (H(2)O)(2)]Cl(3) (where, Nor=norfloxacin) was done during the reaction of silver(I), copper(II) and gold(III) ions with norfloxacin drug ligand. Elemental analysis of CHN, infrared, electronic, (1)H NMR and mass spectra, as well as thermo gravimetric analysis (TG and DTG) and conductivity measurements have been used to characterize the isolated complexes. The powder XRD studies confirm the amorphous nature of the complexes. The norfloxacin ligand is coordinated to Ag(I) and Au(III) ions as a neutral monodentate chelating through the N atom of piperidyl ring, but the copper(II) complex is coordinated through the carbonyl oxygen atom (quinolone group) and the oxygen atom of the carboxylic group. The norfloxacin and their metal complexes have been biologically tested, which resulted in norfloxacin complexes showing moderate activity against the gram positive and gram negative bacteria as well as against fungi.

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  • Publisher Full Text
  • Authors

    Refat MS

    Source

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 68:5 2007 Dec 31 pg 1393-405

    MeSH

    Anti-Bacterial Agents
    Bacteria
    Differential Thermal Analysis
    Electrons
    Kinetics
    Magnetic Resonance Spectroscopy
    Mass Spectrometry
    Microbial Sensitivity Tests
    Norfloxacin
    Protons
    Spectrophotometry, Infrared
    Temperature
    Thermogravimetry
    Transition Elements
    X-Ray Diffraction

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17467332