Abstract

The authors assessed, using the method of sandwich enzyme immunoassay (ELISA), the soluble receptor for interleukin-2 (s-r IL-2). In patients with rheumatoid arthritis mean values of 620.5 = 500.0 u./ml were recorded which was significantly higher than in patients with osteoarthritis (p less than 0.001) (313.3 +/- 155 n./ml) and in healthy controls (181.7 +/- 159.6 n./ml). In patients with rheumatoid arthritis a correlation was found between the activity of the disease expressed by means of Lansbury's index (r = 0.61, p less than 0.01). There was no correlation between s-r IL-2 and the sedimentation rate (r = 0.32, p = n.s.). The author reviews the literature and discusses the hypothesis that s-r IL-2 acts as a competitive inhibitor for interleukin-2.

Authors

Pavelka K

Institution

Rheumatological Research Institute, Prague.

Source

Czechoslovak medicine 14:3 1991 pg 164-72

MeSH

Adolescent
Aged
Arthritis, Rheumatoid
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Receptors, Interleukin-2
Solubility

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1807934