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The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent.

Abstract

Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors' group. Here, the authors report that when administered 10 or 20 microg/1 microl during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep. Furthermore, CBD increased alpha and theta power spectra but diminished delta power spectra. Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN.

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  • Publisher Full Text
  • Authors

    Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Mechoulam R, Drucker-Colín R

    Source

    Behavioral neuroscience 122:6 2008 Dec pg 1378-82

    MeSH

    Animals
    Behavior, Animal
    Cannabidiol
    Cannabis
    Dose-Response Relationship, Drug
    Electroencephalography
    Electromyography
    Hypothalamic Area, Lateral
    Male
    Proto-Oncogene Proteins c-fos
    Random Allocation
    Raphe Nuclei
    Rats
    Rats, Wistar
    Sleep
    Wakefulness

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19045957