Metabolic acidosis in a patient with type 1 diabetes mellitus complicated by methanol and amitriptyline intoxication.
Abstract
Diabetic ketoacidosis (DKA) is a widely known acute metabolic complication of diabetes mellitus (DM), which can be potentially fatal. It is not difficult to diagnose when a patient with DM comes with symptoms such as coma, fruity breath, hyperglycemia, acidosis, and tachypnea. If the patient has not been diagnosed with DM before, then other sicknesses characterized by an increased anion gap should be considered. A 12-year-old boy with type 1 DM and repeated earlier admissions for DKA was admitted to the emergency department in another apparent case of DKA with coma, hyperglycemia, and profound metabolic acidosis. When his condition did not improve with initial treatment, intoxication was suspected as an alternate cause of his condition. Further laboratory tests detected methanol and amitriptyline. The patient underwent hemodialysis and recovered completely. This case illustrates that a seemingly obvious medical condition can mask serious intoxication. This report is the only publication on two different entities characterized by an increased anion gap and at the end the patient has been cured completely without any complications.
Links
Authors
Celik U, Celik T, Avci A, Annagur A, Yilmaz HL, Kucukosmanoglu O, Topaloglu AK, Daglioglu N
Institution
Department of Pediatrics, Division of Pediatric Infectious Disease, Cukurova University, Adana, Turkey. ucelik@cu.edu.tr
Source
European journal of emergency medicine : official journal of the European Society for Emergency Medicine 16:1 2009 Feb pg 45-8MeSH
AmitriptylineAnalgesics, Non-Narcotic
Child
Diabetes Mellitus, Type 1
Diabetic Ketoacidosis
Homeless Youth
Humans
Male
Methanol
Renal Dialysis
Substance-Related Disorders
Pub Type(s)
Case ReportsJournal Article
Language
eng
PubMed ID
19106720
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