Unbound MEDLINE

[The role of endocannabinoid system in physiological and pathological processes in the eye].

Abstract

Plant of Cannabis sativa/ marihuana except for its psychotropic effects possesses a range of pharmacological properties, that has been utilized for medical purposes over a period of millenia. Investigations concerning biochemical mechanism of action of the main and most active pharmacological compound of Cannabis sativa, cannabinoid 9-THC, contributed to the discovery of cannabinoid receptors both in the central nervous system (CNS) and peripheral tissues, that mediated actions of this substance. The discovery made possible identification of a new, endogenous signaling system reffered to as the endocannabinoid system. Besides cannabinoid receptors CB1 and CB2, the system includes it's endogenic ligands (endocannabinoids) and compounds that participate in their biosynthesis and inactivation. Structure and functioning of the endocannabinoid system is conservative in all vertebrates. It's activation with plant, synthetic and endogenous cannabinoids has an influence on multiple physiological and pathological processes within the eye.

Authors

Nadolska K, Goś R

Source

Klinika oczna 110:10-12 2008 pg 392-6

MeSH

Animals
Cannabinoid Receptor Modulators
Cannabinoids
Endocannabinoids
Eye
Humans
Neuroprotective Agents
Receptors, Cannabinoid

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

19195174