Abstract

BACKGROUND
Sodium phosphate containing colonoscopy preparations may cause electrolyte disturbances and calcium-phosphate nephropathy. Decreased body weight is an unexplored risk factor for complications with sodium phosphate ingestion.
AIM
To perform a pharmacokinetic analysis of a single dose of Fleet Phospho-Soda in smaller and larger individuals.
METHODS
Seven subjects weighing <55 kg (Group I) and six weighing >100 kg (Group II) consumed 45 mL Fleet Phospho-Soda. Serum electrolytes were measured. Hydration was closely maintained by monitoring weight, fluid intake and total body water.
RESULTS
Marked increases in serum phosphate were seen in Group I compared to Group II. For example, mean serum phosphate at 120 min was 7.8 +/- 0.5 mg/dL in Group I and 5.1 +/- 0.8 mg/dL in Group II (P < 0.001). Normalized area under the phosphate vs. time curve for Group I was 1120 +/- 190 mg/dL*min and 685 +/- 136 mg/dL*min for Group II (P < 0.001). Twelve-hour urine calcium was lower in Group I (16.4 +/- 7.6 mg) than in Group II (39.2 +/- 7.8 mg, P < 0.001).
CONCLUSIONS
Increased serum phosphate occurs in smaller individuals after ingestion of sodium phosphate preparations, even with strict attention to fluid intake. Smaller body weight poses a potential risk for calcium-phosphate nephropathy.

Links

Publisher Full Text

Authors

Ehrenpreis ED

Institution

Department of Gastroenterology, Highland Park Hospital, NorthShore University HealthSystem, Highland Park, IL 60035, USA. ehrenpreis@gipharm.net

Source

Alimentary pharmacology & therapeutics 29:11 2009 Jun 1 pg 1202-11

MeSH

Adult
Body Composition
Calcium Phosphates
Cathartics
Colonoscopy
Electrolytes
Female
Humans
Hyperphosphatemia
Male
Middle Aged
Phosphates
Risk Factors
Therapeutic Irrigation
Weight Loss

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19298584