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Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study.

Abstract

BACKGROUND/AIM
Serum uric acid level has been suggested to be associated with factors that contribute to the metabolic syndrome. The aim of this study was to investigate the association of serum uric acid level with non-alcoholic fatty liver disease (NAFLD).
METHODS
A cross-sectional study was performed among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China.
RESULTS
The study included 8925 subjects (6008 men) with a mean age of 43 years. The prevalence rates of NAFLD and hyperuricemia were 11.78% and 14.71%, respectively. NAFLD patients had significantly higher serum uric acid levels than controls (370.3+/-86.6 vs. 321.1+/-82.6 micromol/L; P<0.001). The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than in those without hyperuricemia (24.75% vs. 9.54%; P<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (P value for trend <0.001). Multiple regression analysis showed that hyperuricemia was associated with an increased risk of NAFLD (odds ratio [OR]: 1.291, 95% confidence interval [CI]: 1.067-1.564; P<0.001).
CONCLUSION
Serum uric acid level is significantly associated with NAFLD, and elevated serum uric acid level is an independent risk factor for NAFLD.

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  • Publisher Full Text
  • Authors

    Li Y, Xu C, Yu C, Xu L, Miao M

    Institution

    Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, PR China. xiaofu@zju.edu.cn

    Source

    Journal of hepatology 50:5 2009 May pg 1029-34

    MeSH

    Adult
    Biological Markers
    China
    Cross-Sectional Studies
    Fatty Liver
    Female
    Humans
    Male
    Metabolic Syndrome X
    Middle Aged
    Prevalence
    Regression Analysis
    Risk Factors
    Uric Acid

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19299029