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Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress.

Abstract

Neuropathy is the most common complication of diabetes and it is still considered to be relatively refractory to most of the analgesics. The aim of the present study was to explore the antinociceptive effect of a controlled cannabis extract (eCBD) in attenuating diabetic neuropathic pain. Repeated treatment with cannabis extract significantly relieved mechanical allodynia and restored the physiological thermal pain perception in streptozotocin (STZ)-induced diabetic rats without affecting hyperglycemia. In addition, the results showed that eCBD increased the reduced glutathione (GSH) content in the liver leading to a restoration of the defence mechanism and significantly decreased the liver lipid peroxidation suggesting that eCBD provides protection against oxidative damage in STZ-induced diabetes that also strongly contributes to the development of neuropathy. Finally, the nerve growth factor content in the sciatic nerve of diabetic rats was restored to normal following the repeated treatment with eCBD, suggesting that the extract was able to prevent the nerve damage caused by the reduced support of this neurotrophin. These findings highlighted the beneficial effects of cannabis extract treatment in attenuating diabetic neuropathic pain, possibly through a strong antioxidant activity and a specific action upon nerve growth factor.

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  • Publisher Full Text
  • Authors

    Comelli F, Bettoni I, Colleoni M, Giagnoni G, Costa B

    Source

    Phytotherapy research : PTR 23:12 2009 Dec pg 1678-84

    MeSH

    Animals
    Antioxidants
    Blood Glucose
    Cannabis
    Diabetes Mellitus, Experimental
    Diabetic Neuropathies
    Glutathione
    Hyperalgesia
    Hyperglycemia
    Lipid Peroxidation
    Liver
    Male
    Nerve Growth Factor
    Oxidative Stress
    Phytotherapy
    Plant Extracts
    Rats
    Rats, Wistar
    Sciatic Nerve

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19441010