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Cannabinoids in the treatment of cancer.

Abstract

Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. While the various cannabinoids have been examined in a variety of cancer models, recent studies have focused on the role of cannabinoid receptor agonists (both CB(1) and CB(2)) in the treatment of estrogen receptor-negative breast cancer. This review will summarize the anti-cancer properties of the cannabinoids, discuss their potential mechanisms of action, as well as explore controversies surrounding the results.

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  • Publisher Full Text
  • Authors

    Alexander A, Smith PF, Rosengren RJ

    Source

    Cancer letters 285:1 2009 Nov 18 pg 6-12

    MeSH

    Animals
    Antineoplastic Agents, Phytogenic
    Benzoxazines
    Breast Neoplasms
    Cannabinoids
    Cell Proliferation
    Cell Survival
    Female
    Humans
    Male
    Morpholines
    Naphthalenes
    Neoplasms
    Receptor, Cannabinoid, CB1
    Receptor, Cannabinoid, CB2
    Receptors, Estrogen
    Signal Transduction

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19442435