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Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats.

Abstract

Tobacco and cannabis are among the most widely abused drugs in humans, and recently, the functional interaction between nicotine and cannabinoids has been reported. The aim of the present studies is to evaluate the role of CB1 cannabinoid receptors in the reinstatement of nicotine-induced conditioned place preference. Nicotine-induced conditioned place preference was established (three-day nicotine sessions, 0.5 mg/kg), extinguished and reinstated by a priming dose of nicotine. It was shown that the CB1 receptor antagonist AM 251 (0.25 and 0.5 mg/kg) in a dose-dependent manner attenuates the reinstatement of nicotine place conditioning. These studies suggest a role for CB1 cannabinoids receptors in preventing the reinstatement of nicotine addiction.

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  • Authors

    Budzyńska B, Kruk M, Biała G

    Source

    Pharmacological reports : PR 61:2 pg 304-10

    MeSH

    Animals
    Conditioning (Psychology)
    Dose-Response Relationship, Drug
    Extinction, Psychological
    Male
    Nicotine
    Piperidines
    Pyrazoles
    Rats
    Rats, Wistar
    Receptor, Cannabinoid, CB1

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19443943