Abstract

Thirty dogs with spontaneous tumors were irradiated with proton therapy using a novel spot scanning technique to evaluate the safety and efficacy of the system, and to study the acute and late radiation reactions. Nasal tumors, soft tissue sarcomas, and miscellaneous tumors of the head were treated with a median total dose of 52.5 Gy given in 3.5 Gy fractions. Acute effects, late effects, tumor response, and outcome were analyzed. No unexpected radiation reactions were seen, however two dogs did develop in-field osteosarcoma, and one dog developed in-field bone necrosis. Complete response to therapy was seen in 40% (12/30), partial response in 47% (14/30), and no response in 13% (4/30). Median survival for all dogs was 385 days (range of 14-4583 days). Dogs with nasal cavity tumors had a median survival of 385 days (range of 131-1851 days) and dogs with soft tissue sarcomas had a median survival time of 612 days (range of 65-4588 days). Treatment outcome was similar to historical controls. This new proton spot scanning technique proved to be safe and reliable.

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Authors

Mayer-Stankeová S, Fidel J, Wergin MC, Hauser B, Sumová A, Goitein G, Pedroni E, Lomax AJ, Schneider U, Blattmann H, Kaser-Hotz B

Institution

Egg 643, 9055 Buehler, Switzerland.

Source

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 50:3 pg 314-8

MeSH

Animals
Dog Diseases
Dogs
Neoplasms
Protons
Radiation Injuries
Radiotherapy Dosage
Radiotherapy, Conformal

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19507399