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Retinal input instructs alignment of visual topographic maps.Cell. 2009 Oct 02; 139(1):175-85.Cell
Abstract
Sensory information is represented in the brain in the form of topographic maps, in which neighboring neurons respond to adjacent external stimuli. In the visual system, the superior colliculus receives topographic projections from the retina and primary visual cortex (V1) that are aligned. Alignment may be achieved through the use of a gradient of shared axon guidance molecules, or through a retinal-matching mechanism in which axons that monitor identical regions of visual space align. To distinguish between these possibilities, we take advantage of genetically engineered mice that we show have a duplicated functional retinocollicular map but only a single map in V1. Anatomical tracing revealed that the corticocollicular projection bifurcates to align with the duplicated retinocollicular map in a manner dependent on the normal pattern of spontaneous activity during development. These data suggest a general model in which convergent maps use coincident activity patterns to achieve alignment.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Language
eng
PubMed ID
19804762
Citation
Triplett, Jason W., et al. "Retinal Input Instructs Alignment of Visual Topographic Maps." Cell, vol. 139, no. 1, 2009, pp. 175-85.
Triplett JW, Owens MT, Yamada J, et al. Retinal input instructs alignment of visual topographic maps. Cell. 2009;139(1):175-85.
Triplett, J. W., Owens, M. T., Yamada, J., Lemke, G., Cang, J., Stryker, M. P., & Feldheim, D. A. (2009). Retinal input instructs alignment of visual topographic maps. Cell, 139(1), 175-85. https://doi.org/10.1016/j.cell.2009.08.028
Triplett JW, et al. Retinal Input Instructs Alignment of Visual Topographic Maps. Cell. 2009 Oct 2;139(1):175-85. PubMed PMID: 19804762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Retinal input instructs alignment of visual topographic maps.
AU - Triplett,Jason W,
AU - Owens,Melinda T,
AU - Yamada,Jena,
AU - Lemke,Greg,
AU - Cang,Jianhua,
AU - Stryker,Michael P,
AU - Feldheim,David A,
PY - 2009/04/10/received
PY - 2009/06/23/revised
PY - 2009/08/05/accepted
PY - 2009/10/7/entrez
PY - 2009/10/7/pubmed
PY - 2009/10/29/medline
SP - 175
EP - 85
JF - Cell
JO - Cell
VL - 139
IS - 1
N2 - Sensory information is represented in the brain in the form of topographic maps, in which neighboring neurons respond to adjacent external stimuli. In the visual system, the superior colliculus receives topographic projections from the retina and primary visual cortex (V1) that are aligned. Alignment may be achieved through the use of a gradient of shared axon guidance molecules, or through a retinal-matching mechanism in which axons that monitor identical regions of visual space align. To distinguish between these possibilities, we take advantage of genetically engineered mice that we show have a duplicated functional retinocollicular map but only a single map in V1. Anatomical tracing revealed that the corticocollicular projection bifurcates to align with the duplicated retinocollicular map in a manner dependent on the normal pattern of spontaneous activity during development. These data suggest a general model in which convergent maps use coincident activity patterns to achieve alignment.
SN - 1097-4172
UR - https://www.unboundmedicine.com/medline/citation/19804762/Retinal_input_instructs_alignment_of_visual_topographic_maps_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(09)01049-6
DB - PRIME
DP - Unbound Medicine
ER -
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