Unbound MEDLINE

Collagenase Santyl ointment: a selective agent for wound debridement.

Abstract

Enzymatic debridement is a frequently used technique for removal of necrotic tissue from wounds. Proteases with specificity to break down the collagenous materials in necrotic tissues can achieve selective debridement, digesting denatured collagen in eschar while sparing nonnecrotic tissues. This article provides information about the selectivity of a collagenase-based debriding agent, including evidence of its safe and efficacious uses. Recent research has been conducted, investigating the chemical and biological properties of collagenase ointment, including healing in animal models, digestion power on different collagen types, cell migration activity from collagen degradation products, and compatibility with various wound dressings and metal ions. Evidence presented demonstrates that collagenase ointment is an effective, selective, and safe wound debriding agent.

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  • Publisher Full Text
  • Authors

    Shi L, Carson D

    Source

    Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society / WOCN 36:6 Suppl pg S12-6

    MeSH

    Bandages
    Cell Movement
    Clostridium histolyticum
    Debridement
    Humans
    Microbial Collagenase
    Ointments
    Wounds and Injuries

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19918145