Unbound MEDLINE

The role of mucus in cough research.

Abstract

Cough is a defense mechanism for promoting airway hygiene when mucociliary clearance is ineffective due to increased mucus secretion, inflammation, infection, or ciliary dysfunction. Secretions can contribute to airflow limitation and chronic hypersecretion can worsen airway inflammation with retained inflammatory cells and mediators. The focus of the Second Annual Cough Conference has been on cough as a troublesome symptom; but to understand the importance and effectiveness of cough clearance, it is critical to understand airway secretions. The biophysical properties of mucus and phlegm determine how readily these secretions can be cleared by coughing.

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  • Publisher Full Text
  • Authors

    Rubin BK

    Source

    Lung 188 Suppl 1: 2010 Jan pg S69-72

    MeSH

    Antitussive Agents
    Cough
    Expectorants
    Humans
    Mucociliary Clearance
    Mucus
    Research
    Rheology
    Sputum
    Surface Properties
    Viscosity

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19936981