Abstract

Bioassay-guided fractionation of the ethanol extract of the leaves and stems of Illicium simonsii led to the isolation of two new compounds, simonin A (1) and 1-hydroxyl-2- O- β- D-6'-acetyl-glucopyranosyl-4-allylbenzene (2), along with eight known compounds. Their structures were elucidated by spectroscopic analysis. The isolates were tested for anti-oral microbial activity using a microdilution method. Compounds 1 and 3- 6 showed significant activities against oral microbial organisms (Actinomyces viscosus, Streptococcus mutans, Streptococcus sanguis, and Actinomyces naeslundii), with minimum inhibitory concentration (MIC) values ranging from 1.95 to 31.25 µg/mL in vitro.

Links

Publisher Full Text

Authors

Liu JF, Jiang ZY, Geng CA, Zou XB, Shi Y, Ma YB, Zhang XM, Chen JJ

Institution

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China.

Source

Planta medica 76:13 2010 Sep pg 1464-7

MeSH

Allyl Compounds
Anti-Bacterial Agents
Bacteria
Glucosides
Illicium
Microbial Sensitivity Tests
Molecular Structure
Mouth
Plant Extracts
Plant Leaves
Plant Stems
Propanols
Xanthenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20195962