Disseminated intravascular coagulation, meningococcal infection, and ischemic changes affecting the lower extremities: a case study.
A middle-aged woman presented from an outside hospital with a diagnosis of Neisseria meningitidis and meningococcemia. A nonpalpable purpuric skin rash evolved into multiple wounds, with gradual necrosis of bilateral lower and upper extremities. Throughout the course of hospitalization, the patient developed ventricular tachycardia, normocytic anemia, thrombocytosis, Clostridium difficile infection, depression, and transient right eye blindness. The finding of decreased CH50 in the complement cascade was considered as the potential cause of the meningococcemia. The subsequent ischemia and necrosis of extremities were attributed to the systemic effect and trauma ensuing from N. meningitidis.
Highlands Presbyterian/St. Luke's Denver Podiatric Surgical Residency, Denver, CO, USA.
SourceThe Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 49:5 pg 489.e5-9
Complement System Proteins
Disseminated Intravascular Coagulation
Negative-Pressure Wound Therapy
Pub Type(s)Case Reports