Unbound MEDLINE

Maternal ethnicity influences on neonatal respiratory outcomes after antenatal corticosteroid use for anticipated preterm delivery.

Abstract

OBJECTIVE
To explore the influence of maternal ethnicity on neonatal outcomes after antenatal corticosteroid administration.
METHODS
A retrospective review of ethnicity, maternal factors, and neonatal birth outcomes was performed for preterm births at a single institution. Cases were limited to women who received antenatal corticosteroids. The impact of ethnicity on specific neonatal respiratory outcomes and mortality was analyzed by bivariate comparisons and by logistic regression analysis.
RESULTS
Complete ethnicity data were obtained for 548 women. Controlling for gestational age at delivery, diabetes, whether the subject completed a course of steroids, and the dosing of the steroids, logistic regression demonstrated that ethnicity was independently associated with respiratory distress syndrome (compared to Caucasians: African-Americans OR 0.49 (95% CI 0.29-0.85); Filipinos OR 0.45 (95% CI 0.21-0.96).
CONCLUSIONS
Ethnicity is independently associated with neonatal respiratory outcomes after antenatal corticosteroid use. Perhaps individualized dosing of antenatal corticosteroids is needed to further improve neonatal outcomes.

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  • Publisher Full Text

    • Authors

    Haas DM, Sischy AC, McCullough W, Simsiman AJ

    Institution

    Department of OB/GYN, Indiana University School of Medicine, Indianapolis, IN, USA. dahaas@iupui.edu

    Source

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 24:3 2011 Mar pg 516-20

    MeSH

    Adrenal Cortex Hormones
    Adult
    Betamethasone
    Delivery, Obstetric
    Female
    Humans
    Infant, Newborn
    Infant, Premature
    Maternal-Fetal Relations
    Mothers
    Pregnancy
    Pregnancy Outcome
    Premature Birth
    Prenatal Care
    Respiration
    Respiratory Distress Syndrome, Newborn
    Retrospective Studies
    Treatment Outcome
    Young Adult

    Pub Type(s)

    Evaluation Studies
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    20672908