Abstract

BACKGROUND
It is not known whether the clinical course of Japanese sporadic Creutzfeldt-Jakob disease (sCJD) cases differs from that of Caucasian sCJD cases.
PATIENTS AND METHODS
To investigate the clinical course of Japanese sCJD, clinical findings from 29 patients with Japanese MM1-type sCJD were retrospectively evaluated and compared to Caucasian sCJD findings.
RESULTS
Survival of Japanese MM1-type sCJD up to the time of akinetic mutism state is similar to that of Caucasian subjects. However, the total disease duration of Japanese patients was approximately three times longer.
CONCLUSIONS
The present observations indicate that Japanese sCJD cases generally show a longer disease duration because of the longer survival period after reaching the akinetic mutism state.

Links

Publisher Full Text

Authors

Iwasaki Y, Mimuro M, Yoshida M, Kitamoto T, Hashizume Y

Institution

Department of Neurology, Oyamada Memorial Spa Hospital, Yokkaichi, Japan. iwasaki@sc4.so-net.ne.jp

Source

European journal of neurology : the official journal of the European Federation of Neurological Societies 18:7 2011 Jul pg 999-1002

MeSH

Age of Onset
Aged
Aged, 80 and over
Akinetic Mutism
Asian Continental Ancestry Group
Creutzfeldt-Jakob Syndrome
Disease Progression
European Continental Ancestry Group
Female
Humans
Male
Middle Aged
Retrospective Studies
Time

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20722706