Abstract

Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness. The potential for propofol dependency, recreational use, and abuse has only recently been recognized, and several cases of accidental overdose and suicide have emerged. In addition, the first documented case of murder using propofol was reported a few months ago, and a high profile case of suspected homicide with propofol is currently under investigation. A number of analytical methods have been employed to detect and quantify propofol concentrations in biological specimens. The reported propofol-related deaths and postmortem blood and tissue levels are reviewed. Importantly, limitations of propofol detection are discussed, and future considerations are presented. Because propofol has the potential for diversion with lethal consequences, the forensic scientist must have a basic understanding of its clinical indications and uses, pharmacologic properties, and detection methods. In addition, medical institutions should develop systems to prevent and detect diversion of this potential drug of abuse.

Links

Publisher Full Text

Authors

Levy RJ

Institution

Children's National Medical Center, The George Washington University School of Medicine and Health Sciences, Washington, DC 20010. rlevy@cnmc.org

Source

Journal of forensic sciences 56 Suppl 1: 2011 Jan pg S142-7

MeSH

Accidents
Acidosis
Acute Kidney Injury
Bacteremia
Bradycardia
Dyslipidemias
Forensic Toxicology
Health Personnel
Heart Arrest
Heart Failure
Homicide
Humans
Hypertriglyceridemia
Hypnotics and Sedatives
Hypotension
Molecular Structure
Overdose
Pancreatitis
Propofol
Rhabdomyolysis
Sepsis
Substance Abuse Detection
Substance-Related Disorders
Suicide
Syndrome

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

20950316