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- Authors
- Browne SK
- Holland SM
- MESH
- Antibodies, Blocking
- Autoantibodies
- Candidiasis, Chronic Mucocutaneous
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Interferon-gamma
- Interleukin-17
- Interleukin-6
- Interleukins
- Mycobacterium Infections, Atypical
- Polyendocrinopathies, Autoimmune
- Pulmonary Alveolar Proteinosis
- Staphylococcal Skin Infections
- Thymoma
Abstract
PURPOSE OF REVIEW
Anticytokine autoantibodies are an important and emerging mechanism of disease pathogenesis. We will review the clinical and
laboratory features of syndromes in which immunodeficiency is caused by or associated with neutralizing anticytokine autoantibodies.
RECENT FINDINGS
A growing number of patients have been described who demonstrate unique infectious phenotypes associated with neutralizing
autoantibodies that target a particular cytokine known to participate in host defense against the offending organism. Examples
include antigranulocyte macrophage-colony stimulating factor (GM-CSF) autoantibodies and pulmonary alveolar proteinosis; anti-interferon
(IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria (NTM); anti-interleukin-(IL)-6 autoantibodies and severe
staphylococcal skin infection; anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies in patients with mucocutaneous candidiasis
in the setting of both the autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy (APECED) syndrome and in cases
of thymoma.
SUMMARY
Anticytokine autoantibodies have manifestations that are diverse, ranging from asymptomatic to life-threatening. These emerging
and fascinating causes of acquired immunodeficiency may explain some previously idiopathic syndromes.
Links
Authors
Institution
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. brownesa@niaid.nih.gov
Source
Current opinion in allergy and clinical immunology 10:6 2010 Dec pg 534-41MeSH
Antibodies, BlockingAutoantibodies
Candidiasis, Chronic Mucocutaneous
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Interferon-gamma
Interleukin-17
Interleukin-6
Interleukins
Mycobacterium Infections, Atypical
Polyendocrinopathies, Autoimmune
Pulmonary Alveolar Proteinosis
Staphylococcal Skin Infections
Thymoma
Pub Type(s)
Journal ArticleResearch Support, N.I.H., Intramural
Review
Language
eng
PubMed ID
20966748