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Immunodeficiency secondary to anticytokine autoantibodies.

Abstract

PURPOSE OF REVIEW
Anticytokine autoantibodies are an important and emerging mechanism of disease pathogenesis. We will review the clinical and laboratory features of syndromes in which immunodeficiency is caused by or associated with neutralizing anticytokine autoantibodies.
RECENT FINDINGS
A growing number of patients have been described who demonstrate unique infectious phenotypes associated with neutralizing autoantibodies that target a particular cytokine known to participate in host defense against the offending organism. Examples include antigranulocyte macrophage-colony stimulating factor (GM-CSF) autoantibodies and pulmonary alveolar proteinosis; anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria (NTM); anti-interleukin-(IL)-6 autoantibodies and severe staphylococcal skin infection; anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies in patients with mucocutaneous candidiasis in the setting of both the autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy (APECED) syndrome and in cases of thymoma.
SUMMARY
Anticytokine autoantibodies have manifestations that are diverse, ranging from asymptomatic to life-threatening. These emerging and fascinating causes of acquired immunodeficiency may explain some previously idiopathic syndromes.

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  • Authors

    Browne SK, Holland SM

    Source

    Current opinion in allergy and clinical immunology 10:6 2010 Dec pg 534-41

    MeSH

    Antibodies, Blocking
    Autoantibodies
    Candidiasis, Chronic Mucocutaneous
    Granulocyte-Macrophage Colony-Stimulating Factor
    Humans
    Interferon-gamma
    Interleukin-17
    Interleukin-6
    Interleukins
    Mycobacterium Infections, Nontuberculous
    Polyendocrinopathies, Autoimmune
    Pulmonary Alveolar Proteinosis
    Staphylococcal Skin Infections
    Thymoma

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural
    Review

    Language

    eng

    PubMed ID

    20966748