Abstract

We report serial changes of diffusion-weighted imaging (DWI) and single photon emission computed tomography (SPECT) in a patient with Creutzfeldt-Jakob disease with V180I mutation (CJD180). DWI abnormalities in our patient were more predominantly observed in the left cerebral cortex than left basal ganglia. Hemilateral abnormalities progressed over 5 months to involve the contralateral side with increasing DWI signals. At 6 months, SPECT showed hypoperfusion in the left parietal and frontal lobes and the hypoperfusion region spread to the bilateral basal ganglia, right parietal and frontal lobes. SPECT imaging revealed marked cerebral blood flow reduction, predominantly in the cerebral cortex corresponding to brain areas with high-intensity DWI signals. During the follow-up period of CJD180, DWI was more sensitive than conventional FLAIR and T2-weighted images (T2WI) to detect and monitor the progression of abnormal hyperintense lesions. We suggest that serial DWI and SPECT findings are useful for not only early diagnosis of CJD but also for monitoring disease progression.

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Publisher Full Text

Authors

Kono S, Manabe Y, Fujii D, Sakai Y, Narai H, Omori N, Kitamoto T, Abe K

Institution

Department of Neurology, National Hospital Organization Okayama Medical Center, Okayama, Japan.

Source

Journal of the neurological sciences 301:1-2 2011 Feb 15 pg 100-3

MeSH

Age of Onset
Aged
Akinetic Mutism
Brain
Creutzfeldt-Jakob Syndrome
Diffusion Magnetic Resonance Imaging
Disease Progression
Early Diagnosis
Follow-Up Studies
Humans
Male
Mutant Proteins
Mutation, Missense
Point Mutation
PrPSc Proteins
Tomography, Emission-Computed, Single-Photon

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21094959