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Neurocysticercosis in Houston, Texas: an update.

Abstract

Neurocysticercosis, one of the most common parasitic infections of the human nervous system, has emerged as an important infection in the United States. Neurocysticercosis causes significant morbidity associated with acute seizures, chronic epilepsy, and hydrocephalus.We retrospectively identified patients with definitive or probable neurocysticercosis seen at Ben Taub General Hospital, the largest public teaching hospital in Houston, Texas, from September 1997 through December 2005. We collected demographic, clinical, therapeutic, and outcome variables. Neurocysticercosis was classified according to the location of cysts in imaging studies. We compared cases with parenchymal and extraparenchymal disease.We included 111 patients (48 had definitive and 63 probable neurocysticercosis). The mean age was 28.6 years (standard deviation, 13.6 yr), and the male to female ratio was 2:1. Most patients (93%) were Hispanic immigrants. Sixty (54%) patients had parenchymal disease, 22 (20%) intraventricular, 13 (12%) subarachnoid disease, and 13 (12%) had calcifications only. Additionally, 2 patients had hydrocephalus only, and 1 had ocular cysticercosis. Thirteen (40%) of 32 patients with parenchymal disease and 3 (30%) of 10 patients with calcifications had relapsed seizures at follow-up. Extraparenchymal disease was associated with longer duration of hospitalization compared with parenchymal disease. No deaths were identified in our series during a median follow-up of 1 year.Neurocysticercosis has emerged as an important parasitic infection in developed countries as a result of increased migration. With current management, mortality is limited, but there continues to be significant morbidity. Further studies of the epidemiology and pathophysiology of the infection are urgently needed to develop better preventive and therapeutic strategies.

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  • Publisher Full Text
  • Authors

    Serpa JA, Graviss EA, Kass JS, White AC

    Institution

    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA. jaserpaa)bcm.edu

    Source

    Medicine 90:1 2011 Jan pg 81-6

    MeSH

    Adult
    Chi-Square Distribution
    Female
    Hispanic Americans
    Humans
    Logistic Models
    Male
    Neurocysticercosis
    Retrospective Studies
    Statistics, Nonparametric
    Texas

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21200189